‘The second is nanopores, which is our oldest line of study and which has now led to DNA sequencers based on nanopores. We pull person DNA strands through a nanopore and will then browse from the nucleotide sequence. Very lately, we even managed to read out a single protein for The 1st time working with This method. But this line of analysis is not merely about creating tools, but will also about authentic biological concerns.
Our group studies bacterial cell division and is particularly aiming to represent a ‘base up biology’ in synthetic cells that will autonomously divide. Our major curiosity lies in cell division, chromatin structure, and spatial Regulate.
Back in 1991, Sumio Iijima in the NEC Company experienced reported the synthesis of carbon nanotubes. Band structure calculations suggested that these nanotubes could exhibit metallic band conduction. This would be a significant advantage more than the conducting polymers we had explored, which were, in fact, disordered semiconductors providing merely variable-variety hopping conductivity.
Our perform was swiftly followed up by Other folks, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 released their results on transistors comprised of one- and multi-walled carbon nanotubes in Used Physics Letters.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review from the dynamics DNA supercoils and the invention of supercoil hopping
Immediate immobilization of native yeast iso-one cytochrome c on bare gold: quick electron relay to redox enzymes and zeptomole protein-movie voltammetry
You're a Christian. If you can make this kind of synthetic mobile, would you be a single move closer to God, or would the role of God have diminished rather once more?
Atomic force microscopy exhibits that vaccinia topoisomerase IB generates filaments on DNA in the cooperative manner
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‘The fantastically subtle way in which features in character operate by no means ceases to amaze me. If we solve the puzzle of how everyday living arrived into getting, I anticipate that my amazement at the complexity of generation will likely have enhanced and with it my awe for your greatness of your Creator.’
Since 2000 he moved to solitary-molecule biophysics and nanobiology, with study from studies of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more a short while ago his investigation has focused on finding out chromatin structure and cell division with microbes on chip, even though he can also be aiming to in the end Make https://www.ceesdekker.net synthetic cells from The underside up.
Cees Dekker is Distinguished University Professor at TU Delft. Properly trained to be a physicist, he pioneered nanotechnology with lots of discoveries on carbon nanotubes during the nineteen nineties. Due to the fact 2000, he moved to solitary-molecule biophysics and nanobiology. His recent investigation focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, in particular SMC motor protein; and (iii) developing a dwelling artificial cell from lifeless molecules. Dekker is surely an elected member in the KNAW and fellow for the APS plus the IOP.
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2013, controlled shaping of Are living bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations during the handedness of histone tetrasomes